Articles - Dedifferentiated Liposarcoma (DDL) A specially curated list of peer-reviewed articles discussing the latest advancements in the diagnosis and treatment of patients with DDL. Filter by Topic18FFDG PET/CTAbemaciclibAbstractAnlotinibApatinibBI 907828BiomarkerCase ReportCDK4/6 inhibitorChemotherapyClinical TrialsCongressDalpiciclibDedifferentiated LiposarcomaDNA methylationDoxorubicinDurvalumabEribulinGradingGuidelinesImmunotherapyInhibitorLarotrectinibLiposarcomaMDM2MDM2–p53MDM2/CDK4 inhibitorsMRIMultidisciplinary Team (MDT)Myxoid liposarcomaNivolumabNTRKOlaratumabp53PalbociclibPazopanibPembrolizumabRadiotherapyRetroperitoneal LiposarcomaRetroperitoneal sarcomaRibociclibSelitrectinibSoft Tissue SarcomaSurgeryTrabectedinWell-Differentiated Liposarcoma Rapid and Precise Diagnosis of Retroperitoneal Liposarcoma with Deep-Learned Label-Free Molecular Microscopy READ MORE Clinical Implications and Molecular Features of Extracellular Matrix Networks in Soft Tissue Sarcomas READ MORE Safety and Efficacy of the Combination Lurbinectedin plus Doxorubicin from a Phase 1b Trial in Patients with Advanced/Metastatic Soft-Tissue Sarcoma READ MORE Paraneoplastic syndrome due to dedifferentiated liposarcoma producing granulocyte colony-stimulating factor and interleukin-6 READ MORE Current unmet needs in locally advanced (unresectable) or metastatic dedifferentiated liposarcoma, the relevance of progression-free survival as clinical endpoint, and expectations for future clinical trial design: an international Delphi consensus report READ MORE Treatment of patients with dedifferentiated liposarcoma (DDLPS) with the MDM2–p53 antagonist brigimadlin and p53 function: A longitudinal analysis of circulating microRNAs (miRNAs) in a first-in-human phase Ia/Ib study READ MORE Sintilimab, doxorubicin and ifosfamide (AI) as first-line treatment in patients with advanced undifferentiated pleomorphic sarcoma (UPS), synovial sarcoma (SS), myxoid liposarcoma (MLPS) and de-differentiated liposarcoma (DDLPS): A single-arm phase 2 trial READ MORE A phase 2 trial of the CDK4 inhibitor dalpiciclib in well-differentiated or dedifferentiated liposarcoma READ MORE Proteomic analysis in patients with dedifferentiated liposarcoma (DDLPS) in a phase Ia/Ib study of the MDM2–p53 antagonist brigimadlin READ MORE Molecular characteristics of dedifferentiated liposarcoma with broad rhabdomyosarcomatous differentiation READ MORE Quality of life outcomes in patients with resectable dedifferentiated liposarcoma treated with neoadjuvant immunotherapy READ MORE Extracellular Vesicle – MDM2-DNA as a Potential Liquid Biopsy Biomarker for Disease Identification in Retroperitoneal Liposarcoma READ MORE Immune profiling of dedifferentiated liposarcoma and identification of novel antigens for targeted immunotherapy READ MORE Enormous myxoid/round cell liposarcoma: A case report READ MORE UK guidelines for the management of soft tissue sarcomas READ MORE Identification of NINJ1 as a novel prognostic predictor for retroperitoneal liposarcoma READ MORE Superoxide Dismutase Mimetic Avasopasem Manganese Enhances Radiation Therapy Effectiveness in Soft Tissue Sarcomas and Accelerates Wound Healing READ MORE MRI Differential Diagnosis and Guidance for Puncture Biopsy of Musculoskeletal Dedifferentiated Liposarcoma and Well Differentiated Liposarcoma READ MORE Factors Influencing Long-Term Local Recurrence, Distant Metastasis, and Survival in Patients with Soft Tissue Sarcoma of the Extremities Treated with Radiotherapy READ MORE Recurrent retroperitoneal liposarcoma with multiple surgeries: a case report READ MORE PSMA and FDG PET/CT Findings in Patient With Dedifferentiated Liposarcoma and Prostate Cancer Metastases READ MORE New targeted therapies in liposarcoma: state of art and future perspectives READ MORE Diagnosing liposarcoma on (peri)-renal mass biopsy: A clinicopathological study of 30 cases READ MORE GLI1 Co-Amplification in Well-differentiated/Dedifferentiated Liposarcomas: Clinicopathologic and Molecular Analysis of 92 Cases READ MORE A recurrent NTRK1 tyrosine kinase domain mutation pair is characteristic in a subset of dedifferentiated liposarcomas READ MORE First-Line Anlotinib Treatment for Soft-Tissue Sarcoma in Chemotherapy-Ineligible Patients: An Open-Label, Single-Arm, Phase 2 Clinical Trial READ MORE Complete resection after abemaciclib targeted therapy in a patient with mediastinal liposarcoma extensively invading the pericardium and major vessels READ MORE Phase II Study of Eribulin plus Pembrolizumab in Metastatic Soft-tissue Sarcomas: Clinical Outcomes and Biological Correlates READ MORE Afamitresgene autoleucel for advanced synovial sarcoma and myxoid round cell liposarcoma (SPEARHEAD-1): an international, open-label, phase 2 trial READ MORE Best Overall Response-associated Signature to Doxorubicin in Soft Tissue Sarcomas: A Transcriptomic Analysis from ANNOUNCE READ MORE Update on Dosing and Fractionation for Neoadjuvant Radiotherapy for Localized Soft Tissue Sarcoma READ MORE Well-differentiated liposarcomas and dedifferentiated liposarcomas: Systemic treatment options for two sibling neoplasms READ MORE Differential Diagnosis of Lipomatous Tumors Using 18F-Fluorodeoxygulcose Positron Emission Tomography/Computed Tomography: A Retrospective Observational Study READ MORE Spot scanning proton therapy for unresectable bulky retroperitoneal dedifferentiated liposarcoma: a case report READ MORE Superficial dedifferentiated liposarcoma: A clinicopathologic study READ MORE Clinical and surgical effectiveness of the multi-disciplinary standardized management model in the treatment of retroperitoneal liposarcoma: Evidence-based clinical practice experience from Fudan Zhongshan READ MORE Impact of metronomic trabectedin combined with low-dose cyclophosphamide on sarcoma microenvironment and correlation with clinical outcome: results from the TARMIC study READ MORE A randomized, non-comparative phase 2 study of neoadjuvant immune-checkpoint blockade in retroperitoneal dedifferentiated liposarcoma and extremity/truncal undifferentiated pleomorphic sarcoma READ MORE Dedifferentiated liposarcoma of the orbit READ MORE Dedifferentiation in bone and soft tissue sarcomas: How do we define it? What is prognostically relevant? READ MORE Classifying and grading liposarcoma by CT READ MORE Soft Tissue Sarcomas with Chromosomal Alterations in the 12q13-15 Region: Differential Diagnosis and Therapeutic Implications READ MORE ASO Visual Abstract: Adjuvant Palbociclib May be Associated with Delayed Recurrence in Completely Resected Retroperitoneal Liposarcoma: Results of a Single-Institution Retrospective Cohort Study READ MORE Durvalumab plus pazopanib combination in patients with advanced soft tissue sarcomas: a phase II trial READ MORE Case Report: Successful R0 resection in locally advanced retroperitoneal sarcomas READ MORE Primary renal liposarcoma simulating angiomyolipoma READ MORE Neoadjuvant Chemotherapy in High-Grade Myxoid Liposarcoma: Results of the Expanded Cohort of a Randomized Trial From Italian (ISG), Spanish (GEIS), French (FSG), and Polish Sarcoma Groups (PSG) READ MORE Sex-dependent Prognosis of Patients with Advanced Soft Tissue Sarcoma READ MORE A study protocol for an open-label, single-arm, single-center phase I clinical study on tolerability, safety, and efficacy of dalpiciclib combined with apatinib in the treatment of patients with advanced or metastatic sarcoma READ MORE Liposarcoma Masquerading as Immunoglobulin G4–Related Disease READ MORE Atypical lipomatous tumor/well differentiated liposarcoma and related mimics with updates. When is molecular testing most cost-effective, necessary, and indicated? READ MORE Factors predictive of second-line chemotherapy in soft tissue sarcoma: An analysis of the National Genomic Profiling Database READ MORE Preoperative assessment of retroperitoneal Liposarcoma using volume-based 18F-FDG PET/CT: implications for surgical strategy and prognosis READ MORE To Quiesce or Senesce, that is the question for Dedifferentiated Liposarcoma READ MORE MDM2-p53 in liposarcoma: The need for targeted therapies with novel mechanisms of action READ MORE Survival Outcome of Retroperitoneal Sarcomas Treated With a Surgery-First Approach: A Single-Center Experience READ MORE Complete metabolic response after Partially Ablative Radiotherapy (PAR) for bulky retroperitoneal liposarcoma: A case report READ MORE A systematic review of the role of chemotherapy in retroperitoneal sarcoma by the Australia and New Zealand sarcoma association clinical practice guidelines working party READ MORE A Case of Cystic Retroperitoneal Dedifferentiated Liposarcoma Diagnosed by Percutaneous Image-Guided Biopsy READ MORE Retroperitoneal Soft Tissue Sarcoma: Emerging Therapeutic Strategies READ MORE SAR-096: Phase II clinical trial of ribociclib in combination with everolimus in advanced dedifferentiated liposarcoma (DDL), and leiomyosarcoma (LMS) READ MORE Characteristic findings of primary perirenal angiosarcoma on chemical shift subtraction magnetic resonance imaging (CSS-MRI): A case report READ MORE Assessment of The Utility of The Sarcoma DNA Methylation Classifier In Surgical Pathology READ MORE A CT-based radiomics classification model for the prediction of histological type and tumour grade in retroperitoneal sarcoma (RADSARC-R): a retrospective multicohort analysis READ MORE Resection of previously inoperable retroperitoneal liposarcoma READ MORE Low local recurrence rates following marginal surgical resection of non-coelomic Atypical Lipomatous Tumours/Well-differentiated Liposarcomas READ MORE Phase II trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A READ MORE Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma READ MORE Gender Differences in Prognosis After Primary Resection for Retroperitoneal Liposarcoma READ MORE IGF2BP3 as a Prognostic Biomarker in Well-Differentiated/Dedifferentiated Liposarcoma READ MORE Sarcoma care in the era of precision medicine READ MORE Targeting MDM2 in Soft-Tissue Sarcomas (and Other Solid Tumors): The Revival? READ MORE Clinical Activity and Exploratory Resistance Mechanism of Milademetan, an MDM2 Inhibitor, in Intimal Sarcoma with MDM2 Amplification: An Open-Label Phase Ib/II Study READ MORE The MDM2–p53 Antagonist Brigimadlin (BI 907828) in Patients with Advanced or Metastatic Solid Tumors: Results of a Phase Ia, First-in-Human, Dose-Escalation Study READ MORE A century of retroperitoneal soft-tissue sarcoma research: From single center experience to precision oncology? A bibliometric analysis of past, present, and future perspectives READ MORE A phase II study of palbociclib combined with retifanlimab in patients with advanced dedifferentiated liposarcoma READ MORE Treatment of De-Differentiated Liposarcoma in the Era of Immunotherapy READ MORE Brightline-1: phase II/III trial of the MDM2–p53 antagonist BI 907828 versus doxorubicin in patients with advanced DDLPS READ MORE A Single-Arm Phase II Trial of Sitravatinib in Advanced Well-Differentiated/Dedifferentiated Liposarcoma READ MORE 42O A phase Ia/b, dose-escalation and expansion study evaluating the MDM2–p53 antagonist BI 907828 in patients with solid tumours: Safety and efficacy in patients with dedifferentiated liposarcoma (DDLPS) READ MORE A First-in-Human Phase I Study of Milademetan, an MDM2 Inhibitor, in Patients With Advanced Liposarcoma, Solid Tumors, or Lymphomas READ MORE Exploring the landscape of immunotherapy approaches in sarcomas READ MORE Targeting the MDM2-p53 pathway in dedifferentiated liposarcoma READ MORE ASO Visual Abstract: Clinical Impact of External Beam Radiotherapy for Surgically Resected Primary Retroperitoneal Liposarcoma READ MORE Activity of Cabazitaxel in Metastatic or Inoperable Locally Advanced Dedifferentiated Liposarcoma READ MORE Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma READ MORE Established and Experimental Systemic Treatment Options for Advanced Liposarcoma READ MORE First-line chemotherapy in advanced intra-abdominal well-differentiated/dedifferentiated liposarcoma: An EORTC Soft Tissue and Bone Sarcoma Group retrospective analysis READ MORE Selinexor in Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial READ MORE Co-Targeting of MDM2 and CDK4/6 with Siremadlin and Ribociclib for the Treatment of Patients with Well-Differentiated or Dedifferentiated Liposarcoma: Results from a Proof-of-Concept, Phase Ib Study READ MORE Biology and Management of Dedifferentiated Liposarcoma: State of the Art and Perspectives READ MORE Soft tissue and visceral sarcomas: ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up☆ READ MORE Defining the role of neoadjuvant systemic therapy in high-risk retroperitoneal sarcoma: A multi-institutional study from the Transatlantic Australasian Retroperitoneal Sarcoma Working Group READ MORE Clinical activity of pembrolizumab (P) in undifferentiated pleomorphic sarcoma (UPS) and dedifferentiated/pleomorphic liposarcoma (LPS): Final results of SARC028 expansion cohorts READ MORE Survival Benefit of the Surgical Management of Retroperitoneal Sarcoma in a Reference Center: A Nationwide Study of the French Sarcoma Group from the NetSarc Database READ MORE Radiotherapy for retroperitoneal liposarcoma: A report from the Transatlantic Retroperitoneal Sarcoma Working Group READ MORE Clinical and Molecular Spectrum of Liposarcoma READ MORE Facebook Twitter Linkedin
